NF-Y (CBF) regulation in specific cell types and mouse models.
Biochim Biophys Acta Gene Regul Mech
; 1860(5): 598-603, 2017 May.
Article
em En
| MEDLINE
| ID: mdl-27815195
ABSTRACT
The CCAAT-binding factor CBF/NF-Y is needed for cell proliferation and early embryonic development. NF-Y can regulate the expression of different cell type-specific genes that are activated by various physiological signaling pathways. Dysregulation of NF-Y was observed in pathogenic conditions in humans such as scleroderma, neurodegenerative disease, and cancer. Conditional inactivation of the NF-YA gene in mice demonstrated that NF-Y activity is essential for normal tissue homeostasis, survival, and metabolic function. Altogether, NF-Y is an essential transcription factor that plays a critical role in mammalian development, from the early stages to adulthood, and in human pathogenesis. This article is part of a Special Issue entitled Nuclear Factor Y in Development and Disease, edited by Prof. Roberto Mantovani.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Neurodegenerativas
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Fator de Ligação a CCAAT
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Esclerodermia Difusa
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Proteínas de Neoplasias
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Neoplasias Experimentais
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article