Peritoneal carcinomatosis of colorectal cancer: novel clinical and molecular outcomes.
Am J Surg
; 213(2): 377-387, 2017 Feb.
Article
em En
| MEDLINE
| ID: mdl-27816197
ABSTRACT
BACKGROUND:
The objective of this study was to identify the prognostic impact of parameters in peritoneal carcinomatosis from colorectal cancer.METHODS:
We collected data from patients treated by cytoreductive surgery and Hyperthermic Intraperitoneal Chemotherapy for peritoneal carcinomatosis secondary to colorectal cancer.RESULTS:
Ninety-one procedures were performed. In univariate analysis, an increased peritoneal cancer index was associated with decreased survival (P < .001). The presence of signet ring cells was associated to a decrease in survival from 45.8 to 12.1 months (P < .001). Microsatellite sequences instability status was the only molecular prognostic factor correlated with an increase in median disease-free survival 12.4 vs 24.9 months (P = .01). The presence of a mucinous component was associated with a decreased of survival from 51.9 to 35.1 months (P = .02).CONCLUSIONS:
Clinical factors were affecting the survival of patients. The absence of signet ring cells and mucinous component and the presence of microsatellite sequences instability may be favorable prognostic factors.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Peritoneais
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Neoplasias Retais
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Adenocarcinoma
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Neoplasias do Colo
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article