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Discovery of novel pyrrolidineoxy-substituted heteroaromatics as potent and selective PI3K delta inhibitors with improved physicochemical properties.
Hoegenauer, Klemens; Soldermann, Nicolas; Hebach, Christina; Hollingworth, Gregory J; Lewis, Ian; von Matt, Anette; Smith, Alexander B; Wolf, Romain M; Wilcken, Rainer; Haasen, Dorothea; Burkhart, Christoph; Zécri, Frédéric.
Afiliação
  • Hoegenauer K; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland. Electronic address: klemens.hoegenauer@novartis.com.
  • Soldermann N; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.
  • Hebach C; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.
  • Hollingworth GJ; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.
  • Lewis I; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.
  • von Matt A; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.
  • Smith AB; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.
  • Wolf RM; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.
  • Wilcken R; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.
  • Haasen D; Center for Proteomic Chemistry, Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.
  • Burkhart C; Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.
  • Zécri F; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.
Bioorg Med Chem Lett ; 26(23): 5657-5662, 2016 12 01.
Article em En | MEDLINE | ID: mdl-27816514
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirrolidinas / Quinazolinas / Inibidores de Fosfoinositídeo-3 Quinase Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirrolidinas / Quinazolinas / Inibidores de Fosfoinositídeo-3 Quinase Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article