Emulating proton-induced conformational changes in the vesicular monoamine transporter VMAT2 by mutagenesis.

Yaffe, Dana; Vergara-Jaque, Ariela; Forrest, Lucy R; Schuldiner, Shimon

Yaffe, Dana; Vergara-Jaque, Ariela; Forrest, Lucy R; Schuldiner, Shimon.

Afiliação

Yaffe D; Department of Biological Chemistry, Alexander Silberman Institute of Life Sciences, Hebrew University, Jerusalem 91904, Israel.
Vergara-Jaque A; Computational Structural Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
Forrest LR; Computational Structural Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
Schuldiner S; Department of Biological Chemistry, Alexander Silberman Institute of Life Sciences, Hebrew University, Jerusalem 91904, Israel; shimon.schuldiner@huji.ac.il.

Proc Natl Acad Sci U S A ; 113(47): E7390-E7398, 2016 11 22.

Article em En | MEDLINE | ID: mdl-27821772

Assuntos

Mutação; Reserpina/metabolismo; Tetrabenazina/metabolismo; Proteínas Vesiculares de Transporte de Monoamina/química; Proteínas Vesiculares de Transporte de Monoamina/genética; Animais; Sítios de Ligação; Citoplasma/genética; Citoplasma/metabolismo; Células HEK293; Humanos; Modelos Moleculares; Conformação Proteica; Prótons; Ratos; Proteínas Vesiculares de Transporte de Monoamina/metabolismo

Palavras-chave

ion coupling; neurotransmitter transporter; reserpine; tetrabenazine

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Reserpina / Tetrabenazina / Proteínas Vesiculares de Transporte de Monoamina / Mutação Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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