Ultimate Clinical Outcomes of Appendiceal Mucinous Neoplasm of Uncertain Malignant Potential.
Ann Surg Oncol
; 24(4): 974-982, 2017 Apr.
Article
em En
| MEDLINE
| ID: mdl-27822629
ABSTRACT
BACKGROUND:
The clinical outcome of appendiceal mucinous neoplasm (AMN) is not well understood. This study aimed to compare the long-term outcome for the uncertain malignant potential (UMP) subtype of AMNs with those of the mucinous adenoma (MA) and mucinous adenocarcinoma (MAC) subtypes.METHODS:
In this study, AMNs were classified into three groups (MA, UMP, and MAC), and clinical characteristics, overall survival (OS), and progression-free survival (PFS) were compared among the three groups.RESULTS:
The study included 65 AMN patients (26 MA, 20 UMP, and 19 MAC patients). The median follow-up period was 87 months (range 0.3-311.0) months. The symptoms at diagnosis and the presence of pseudomyxoma peritonei were more common in the MAC group than in the MA group (P = 0.012) or the UMP group (P < 0.001). The 5-year OS rates were 95.5% for the MA group, 93.8% for the UMP group, and 78.3% for the MAC group (P < 0.001), and the 5-year PFS rates were 95.2% for the MA group, 95% for the UMP group, and 36.8% for the MAC group (P < 0.001). Thus, OS and PFS did not differ significantly in the MA and UMP groups (P = 0.884 and 0.345, respectively). In contrast, the OS and PFS of the MAC group were worse than in the MA group (P = 0.017 and <0.001, respectively) or the UMP group (P < 0.001 and 0.001, respectively).CONCLUSIONS:
The long-term outcome for UMP tumors is similar to that for MA tumors and significantly better than for MAC tumors.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias do Apêndice
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Neoplasias Peritoneais
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Pseudomixoma Peritoneal
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Cistadenoma Mucinoso
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Adenocarcinoma Mucinoso
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Recidiva Local de Neoplasia
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article