Adhesion GPCRs as Novel Actors in Neural and Glial Cell Functions: From Synaptogenesis to Myelination.
Handb Exp Pharmacol
; 234: 275-298, 2016.
Article
em En
| MEDLINE
| ID: mdl-27832492
ABSTRACT
Adhesion G-protein-coupled receptors (aGPCRs) are emerging as key regulators of nervous system development and health. aGPCRs can regulate many aspects of neural development, including cell signaling, cell-cell and cell-matrix interactions, and, potentially, mechanosensation. Here, we specifically focus on the roles of several aGPCRs in synapse biology, dendritogenesis, and myelinating glial cell development. The lessons learned from these examples may be extrapolated to other contexts in the nervous system and beyond.
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Base de dados:
MEDLINE
Assunto principal:
Adesão Celular
/
Membrana Celular
/
Neuroglia
/
Receptores Acoplados a Proteínas G
/
Sinapses Elétricas
/
Bainha de Mielina
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Fibras Nervosas Mielinizadas
/
Neurônios
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article