RANKL induces Bach1 nuclear import and attenuates Nrf2-mediated antioxidant enzymes, thereby augmenting intracellular reactive oxygen species signaling and osteoclastogenesis in mice.

Kanzaki, Hiroyuki; Shinohara, Fumiaki; Itohiya, Kanako; Yamaguchi, Yuuki; Katsumata, Yuta; Matsuzawa, Masazumi; Fukaya, Sari; Miyamoto, Yutaka; Wada, Satoshi; Nakamura, Yoshiki

Kanzaki, Hiroyuki; Shinohara, Fumiaki; Itohiya, Kanako; Yamaguchi, Yuuki; Katsumata, Yuta; Matsuzawa, Masazumi; Fukaya, Sari; Miyamoto, Yutaka; Wada, Satoshi; Nakamura, Yoshiki.

Afiliação

Kanzaki H; Maxillo-Oral Disorders, Tohoku University Hospital, Sendai, Japan; kanzaki-h@tsurumi-u.ac.jp.
Shinohara F; Department of Orthodontics, School of Dental Medicine, Tsurumi University, Yokohama, Japan; and.
Itohiya K; Oral Microbiology, Tohoku University Graduate School of Dentistry, Sendai, Japan.
Yamaguchi Y; Department of Orthodontics, School of Dental Medicine, Tsurumi University, Yokohama, Japan; and.
Katsumata Y; Department of Orthodontics, School of Dental Medicine, Tsurumi University, Yokohama, Japan; and.
Matsuzawa M; Department of Orthodontics, School of Dental Medicine, Tsurumi University, Yokohama, Japan; and.
Fukaya S; Department of Orthodontics, School of Dental Medicine, Tsurumi University, Yokohama, Japan; and.
Miyamoto Y; Department of Orthodontics, School of Dental Medicine, Tsurumi University, Yokohama, Japan; and.
Wada S; Department of Orthodontics, School of Dental Medicine, Tsurumi University, Yokohama, Japan; and.
Nakamura Y; Department of Orthodontics, School of Dental Medicine, Tsurumi University, Yokohama, Japan; and.

FASEB J ; 31(2): 781-792, 2017 02.

Article em En | MEDLINE | ID: mdl-27836987

Assuntos

Fatores de Transcrição de Zíper de Leucina Básica/metabolismo; Fator 2 Relacionado a NF-E2/metabolismo; Osteoclastos/fisiologia; Ligante RANK/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Transporte Ativo do Núcleo Celular/fisiologia; Animais; Fatores de Transcrição de Zíper de Leucina Básica/genética; Sobrevivência Celular; Regulação da Expressão Gênica/fisiologia; Camundongos; Fator 2 Relacionado a NF-E2/genética; Ligante RANK/genética; Células RAW 264.7; Transdução de Sinais/fisiologia

Palavras-chave

JNK; NQO1; aminolevulinic acid; bone destruction; heme

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoclastos / Espécies Reativas de Oxigênio / Fatores de Transcrição de Zíper de Leucina Básica / Fator 2 Relacionado a NF-E2 / Ligante RANK Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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