Impact of a maternal immunization program against pertussis in a developing country.
Vaccine
; 34(50): 6223-6228, 2016 12 07.
Article
em En
| MEDLINE
| ID: mdl-27847175
ABSTRACT
BACKGROUND:
Pertussis disease is a growing concern for developing countries. In Argentina, rates of illness and death peaked in 2011. More than 50% of fatalities due to pertussis occurred in infants younger than two months of age, too young for vaccination. In 2012, the government offered immunization with a vaccine containing Tdap to all pregnant women after 20weeks of gestation with the intent of reducing morbidity and mortality in young infants.METHODS:
Maternal acellular pertussis vaccine impact on reducing infant disease burden was estimated based on data from the Argentinean Health Surveillance System. We divided Argentinean states in two groups experiencing high (>50) and low (⩽50) Tdap vaccine coverage and compared these two groups using a Bayesian structural time-series model. Low coverage regions were used as a control group, and the time series were compared before and after the implementation of the Tdap program.FINDINGS:
We observed a relative reduction of 51% (95% CI [-67%, -35%]; p=0.001) in pertussis cases in high coverage states in comparison with the low coverage areas. Analysis of infants between two and six months showed a 44% (95% CI [-66%, -24%]; p=0.001) reduction in illness. Number of deaths was highest in 2011 with 76 fatalities, for an incidence rate of 2.9 per 100,000. Comparing with 2011, rates decreased by 87% to 10 subjects, or 0.9 per 100,000 in 2013.INTERPRETATION:
We show an age-dependent protective effect of maternal Tdap immunization in a developing country for infants younger than six months.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Coqueluche
/
Vacinação
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Programas de Imunização
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Transmissão de Doença Infecciosa
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Vacinas contra Difteria, Tétano e Coqueluche Acelular
/
Gestantes
Tipo de estudo:
Incidence_studies
/
Prognostic_studies
Limite:
Child
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Child, preschool
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Female
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Humans
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Infant
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Male
/
Newborn
País como assunto:
America do sul
/
Argentina
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article