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The Future Prospects of Immune Therapy in Gastric and Esophageal Adenocarcinoma.
Shaib, Walid L; Nammour, Jean Paul A; Gill, Harpaul; Mody, Mayur; Saba, Nabil F.
Afiliação
  • Shaib WL; Department of Hematology and Oncology, Winship Cancer Institute, Emory University, 1365 Clifton Rd NE, Atlanta, GA 30322, USA. wshaib@emory.edu.
  • Nammour JP; Department of Medicine, Balamand University, Beirut 1300, Lebanon. jeanpaul.nammour@gmail.com.
  • Gill H; Department of Internal Medicine, Emory University, Atlanta, GA 30322, USA. harpaul.s.gill@emory.edu.
  • Mody M; Department of Internal Medicine, Emory University, Atlanta, GA 30322, USA. mdmody@emory.edu.
  • Saba NF; Department of Hematology and Oncology, Winship Cancer Institute, Emory University, 1365 Clifton Rd NE, Atlanta, GA 30322, USA. nfsaba@emory.edu.
J Clin Med ; 5(11)2016 Nov 14.
Article em En | MEDLINE | ID: mdl-27854242
The prognosis of esophageal cancers is poor and novel approaches are urgently needed. Despite improvements in outcomes with transtuzumab and ramucirumab, these improvements added an average of only 2 to 3 months with a median overall survival reported to be around 1 year. Comprehensive genomic sequencing has defined some molecular alterations with potential targets, but the majority of patients still do not benefit from druggable targets. Breakthroughs in immune checkpoint blockade have provided new therapeutic options in many cancers. Programmed death ligand 1 (PDL1) overexpression, a possible biomarker predicting response to immune checkpoint inhibitors, approaches forty percent in esophageal and gastric cancers. Translational and molecular studies have shown that esophageal cancers are possible candidate malignancies for immune checkpoint inhibition. In this review, we plan to highlight the mechanisms, preclinical, and early clinical data that provide insight on the role of immune therapeutics in esophageal cancers.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2016 Tipo de documento: Article