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Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism.
Tamura, Tatsuya; Noda, Hiroshi; Joyashiki, Eri; Hoshino, Maiko; Watanabe, Tomoyuki; Kinosaki, Masahiko; Nishimura, Yoshikazu; Esaki, Tohru; Ogawa, Kotaro; Miyake, Taiji; Arai, Shinichi; Shimizu, Masaru; Kitamura, Hidetomo; Sato, Haruhiko; Kawabe, Yoshiki.
Afiliação
  • Tamura T; Research Division, Chugai Pharmaceutical Co., Ltd., 1-135, Komakado, Gotemba, Shizuoka 412-8513, Japan.
  • Noda H; Research Division, Chugai Pharmaceutical Co., Ltd., 1-135, Komakado, Gotemba, Shizuoka 412-8513, Japan.
  • Joyashiki E; Research Division, Chugai Pharmaceutical Co., Ltd., 1-135, Komakado, Gotemba, Shizuoka 412-8513, Japan.
  • Hoshino M; Research Division, Chugai Pharmaceutical Co., Ltd., 1-135, Komakado, Gotemba, Shizuoka 412-8513, Japan.
  • Watanabe T; Research Division, Chugai Pharmaceutical Co., Ltd., 1-135, Komakado, Gotemba, Shizuoka 412-8513, Japan.
  • Kinosaki M; Research Division, Chugai Pharmaceutical Co., Ltd., 1-135, Komakado, Gotemba, Shizuoka 412-8513, Japan.
  • Nishimura Y; Research Division, Chugai Pharmaceutical Co., Ltd., 1-135, Komakado, Gotemba, Shizuoka 412-8513, Japan.
  • Esaki T; Research Division, Chugai Pharmaceutical Co., Ltd., 1-135, Komakado, Gotemba, Shizuoka 412-8513, Japan.
  • Ogawa K; Research Division, Chugai Pharmaceutical Co., Ltd., 1-135, Komakado, Gotemba, Shizuoka 412-8513, Japan.
  • Miyake T; Research Division, Chugai Pharmaceutical Co., Ltd., 1-135, Komakado, Gotemba, Shizuoka 412-8513, Japan.
  • Arai S; Research Division, Chugai Pharmaceutical Co., Ltd., 1-135, Komakado, Gotemba, Shizuoka 412-8513, Japan.
  • Shimizu M; Research Division, Chugai Pharmaceutical Co., Ltd., 1-135, Komakado, Gotemba, Shizuoka 412-8513, Japan.
  • Kitamura H; Research Division, Chugai Pharmaceutical Co., Ltd., 1-135, Komakado, Gotemba, Shizuoka 412-8513, Japan.
  • Sato H; Research Division, Chugai Pharmaceutical Co., Ltd., 1-135, Komakado, Gotemba, Shizuoka 412-8513, Japan.
  • Kawabe Y; Research Division, Chugai Pharmaceutical Co., Ltd., 1-135, Komakado, Gotemba, Shizuoka 412-8513, Japan.
Nat Commun ; 7: 13384, 2016 11 18.
Article em En | MEDLINE | ID: mdl-27857062
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Receptor Tipo 1 de Hormônio Paratireóideo / Imidazolidinas / Hipoparatireoidismo Tipo de estudo: Diagnostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Receptor Tipo 1 de Hormônio Paratireóideo / Imidazolidinas / Hipoparatireoidismo Tipo de estudo: Diagnostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article