Endogenous Telomerase Reverse Transcriptase N-Terminal Tagging Affects Human Telomerase Function at Telomeres In Vivo.

Chiba, Kunitoshi; Vogan, Jacob M; Wu, Robert A; Gill, Manraj S; Zhang, Xiaozhu; Collins, Kathleen; Hockemeyer, Dirk

Chiba, Kunitoshi; Vogan, Jacob M; Wu, Robert A; Gill, Manraj S; Zhang, Xiaozhu; Collins, Kathleen; Hockemeyer, Dirk.

Afiliação

Chiba K; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.
Vogan JM; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.
Wu RA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.
Gill MS; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.
Zhang X; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.
Collins K; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.
Hockemeyer D; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA hockemeyer@berkeley.edu.

Mol Cell Biol ; 37(3)2017 02 01.

Article em En | MEDLINE | ID: mdl-27872149

Assuntos

Epitopos/metabolismo; Telomerase/metabolismo; Telômero/metabolismo; Southern Blotting; Edição de Genes; Genótipo; Células-Tronco Embrionárias Humanas/metabolismo; Humanos; Fenótipo; Sequências Repetitivas de Ácido Nucleico/genética; Homeostase do Telômero

Palavras-chave

CRISPR/Cas9; embryonic stem cells; genome editing; pluripotent stem cells; telomerase; telomeres

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Telômero / Telomerase / Epitopos Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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