Correlation of structure with T cell responses of the three members of the HLA-DRw52 allelic series.
J Exp Med
; 170(3): 1027-32, 1989 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-2788702
ABSTRACT
A third allele at the DRB3 locus, DRw52c, represents an intermediate sequence between DRw52a and DRw52b and may have arisen by a gene conversion-like event. The recognition of cells bearing these molecules by a number of alloreactive and antigen-specific DR-restricted T cell clones was analyzed. On the basis of a theoretical model of HLA class II structure, distinct amino acid clusters have been identified as motifs controlling TCR recognition. These are located both in the cleft and in the alpha-helical edge of the MHC class II recognition platform. Motifs shared between two alleles may restrict public T cell clones.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Antígenos HLA-DR
/
Alelos
Limite:
Humans
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article