Ailanthusins A-G and nor-lupane triterpenoids from Ailanthus triphysa.
Phytochemistry
; 134: 98-105, 2017 Feb.
Article
em En
| MEDLINE
| ID: mdl-27890583
ABSTRACT
Bioactivity-guided chemical investigation of the CH2Cl2 and CH2Cl2MeOH extracts of the stem and stem bark material of Ailanthus tryphysa (Simaroubaceae) led to the isolation of five cycloapotirucallanes, ailanthusins A-E, two malabaricanes, ailanthusins F-G, and one nor-lupane triterpenoid, 29-nor-lup-1-ene-3,20-dione along with twenty known compounds. Their structures were elucidated through the application of extensive spectroscopic methods, and the structure of ailanthusin A was further confirmed by single crystal X-ray analysis. Several malabaricane derivatives were prepared from malabaricol and, together with some of the isolates, were evaluated for their cytotoxic activities against human cancer and normal cell lines.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Triterpenos
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Ailanthus
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Antineoplásicos Fitogênicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article