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Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis.
Lotta, Luca A; Scott, Robert A; Sharp, Stephen J; Burgess, Stephen; Luan, Jian'an; Tillin, Therese; Schmidt, Amand F; Imamura, Fumiaki; Stewart, Isobel D; Perry, John R B; Marney, Luke; Koulman, Albert; Karoly, Edward D; Forouhi, Nita G; Sjögren, Rasmus J O; Näslund, Erik; Zierath, Juleen R; Krook, Anna; Savage, David B; Griffin, Julian L; Chaturvedi, Nishi; Hingorani, Aroon D; Khaw, Kay-Tee; Barroso, Inês; McCarthy, Mark I; O'Rahilly, Stephen; Wareham, Nicholas J; Langenberg, Claudia.
Afiliação
  • Lotta LA; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
  • Scott RA; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
  • Sharp SJ; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
  • Burgess S; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
  • Luan J; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
  • Tillin T; Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, United Kingdom.
  • Schmidt AF; Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, United Kingdom.
  • Imamura F; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
  • Stewart ID; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
  • Perry JR; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
  • Marney L; MRC Human Nutrition Research, Cambridge, United Kingdom.
  • Koulman A; MRC Human Nutrition Research, Cambridge, United Kingdom.
  • Karoly ED; Metabolon, Morrisville, North Carolina, United States of America.
  • Forouhi NG; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
  • Sjögren RJ; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
  • Näslund E; Division of Surgery, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.
  • Zierath JR; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
  • Krook A; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
  • Savage DB; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
  • Griffin JL; Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
  • Chaturvedi N; MRC Human Nutrition Research, Cambridge, United Kingdom.
  • Hingorani AD; Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
  • Khaw KT; Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, United Kingdom.
  • Barroso I; Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, United Kingdom.
  • McCarthy MI; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
  • O'Rahilly S; Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
  • Wareham NJ; Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
  • Langenberg C; Oxford Centre for Diabetes, Endocrinology and Metabolism, and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
PLoS Med ; 13(11): e1002179, 2016 Nov.
Article em En | MEDLINE | ID: mdl-27898682
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Predisposição Genética para Doença / Diabetes Mellitus Tipo 2 / Análise da Randomização Mendeliana / Aminoácidos de Cadeia Ramificada Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adult / Aged / Humans / Male / Middle aged País como assunto: Europa Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Predisposição Genética para Doença / Diabetes Mellitus Tipo 2 / Análise da Randomização Mendeliana / Aminoácidos de Cadeia Ramificada Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adult / Aged / Humans / Male / Middle aged País como assunto: Europa Idioma: En Ano de publicação: 2016 Tipo de documento: Article