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Body composition and bone mineral status in patients with Turner syndrome.
Shi, Kun; Liu, Li; He, Yao-Juan; Li, Duan; Yuan, Lian-Xiong; Lash, Gendie E; Li, Li.
Afiliação
  • Shi K; Department of Gynecology and Obstetrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jingsui Road, Guangzhou, Guangdong, 510160, China.
  • Liu L; Department of Pediatrics Endocrinology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jingsui Road, Guangzhou, Guangdong 510160, China.
  • He YJ; Department of Gynecology and Obstetrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jingsui Road, Guangzhou, Guangdong, 510160, China.
  • Li D; Department of Pediatrics Endocrinology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jingsui Road, Guangzhou, Guangdong 510160, China.
  • Yuan LX; Department of Biostatistics, Sun Yixian University, 74 Zhong Shan Er Road, Guangzhou, Guangdong, 510515, China.
  • Lash GE; Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jingsui Road, Guangzhou, Guangdong, 510160, China.
  • Li L; Department of Gynecology and Obstetrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jingsui Road, Guangzhou, Guangdong, 510160, China.
Sci Rep ; 6: 38026, 2016 11 30.
Article em En | MEDLINE | ID: mdl-27901060
ABSTRACT
Turner syndrome (TS) is associated with decreased bone mineral density and increased fracture rate. However, the developmental trajectory of bone density or body composition in patients with TS is still unclear. The present study tested the hypothesis that different karyotypes and/or age contributes to abnormal body composition and decreased bone mineral status parameters in patients with TS. This study included 24 girls with TS, in which 13 girls exhibited X0 karyotype and 11 had mosaicism. Quantitative ultrasound (QUS) assessed the bone mineral status of the calcaneus, including bone mineral density (BMD), amplitude-dependent speed of sound (AD-SOS), broadband ultrasound attenuation (BUA) and InBody 770 assessed body composition. Pearson's test was performed to correlate measured parameters with patient age. The body composition and bone mineral status parameters were not significantly influenced by patient karyotype. There was a correlation between patient age and AD-SOS (r = -0.61, P = 0.002) and BUA (r = 0.50, P = 0.013) but not BMD (r = -0.19, P = 0.379). In conclusion, there was no effect of karyotype on body composition or body mineral status. Bone mineral status, as evidenced by changes in AD-SOS and BUA, alters with age regardless of karyotype. The developmental trajectory demonstrated in the current study warrants further validation in a longitudinal study.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome de Turner / Composição Corporal / Densidade Óssea / Mosaicismo Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome de Turner / Composição Corporal / Densidade Óssea / Mosaicismo Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article