Combined Inhibition of Both p110&#945; and p110ß Isoforms of Phosphatidylinositol 3-Kinase Is Required for Sustained Therapeutic Effect in PTEN-Deficient, ER<sup>+</sup> Breast Cancer.

Hosford, Sarah R; Dillon, Lloye M; Bouley, Stephanie J; Rosati, Rachele; Yang, Wei; Chen, Vivian S; Demidenko, Eugene; Morra, Rocco P; Miller, Todd W

Combined Inhibition of Both p110α and p110ß Isoforms of Phosphatidylinositol 3-Kinase Is Required for Sustained Therapeutic Effect in PTEN-Deficient, ER⁺ Breast Cancer.

Hosford, Sarah R; Dillon, Lloye M; Bouley, Stephanie J; Rosati, Rachele; Yang, Wei; Chen, Vivian S; Demidenko, Eugene; Morra, Rocco P; Miller, Todd W.

Afiliação

Hosford SR; Depts. of Molecular & Systems Biology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Dillon LM; Depts. of Molecular & Systems Biology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Bouley SJ; Depts. of Molecular & Systems Biology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Rosati R; Depts. of Molecular & Systems Biology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Yang W; Depts. of Molecular & Systems Biology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Chen VS; Depts. of Molecular & Systems Biology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Demidenko E; Depts. of Community & Family Medicine, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Morra RP; Depts. of Molecular & Systems Biology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Miller TW; Depts. of Molecular & Systems Biology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH.

Clin Cancer Res ; 23(11): 2795-2805, 2017 Jun 01.

Article em En | MEDLINE | ID: mdl-27903677

Assuntos

Neoplasias da Mama/tratamento farmacológico; Neoplasias da Mama/genética; Classe I de Fosfatidilinositol 3-Quinases/genética; Classe Ia de Fosfatidilinositol 3-Quinase/genética; Animais; Apoptose/efeitos dos fármacos; Neoplasias da Mama/patologia; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Classe I de Fosfatidilinositol 3-Quinases/antagonistas & inibidores; Receptor alfa de Estrogênio/genética; Feminino; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Camundongos; PTEN Fosfo-Hidrolase/genética; Inibidores de Fosfoinositídeo-3 Quinase; Proteínas Proto-Oncogênicas c-akt/genética; Proteína do Retinoblastoma/genética; Transdução de Sinais/efeitos dos fármacos; Tiazóis/administração & dosagem

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Classe I de Fosfatidilinositol 3-Quinases / Classe Ia de Fosfatidilinositol 3-Quinase Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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