Pharos: Collating protein information to shed light on the druggable genome.
Nucleic Acids Res
; 45(D1): D995-D1002, 2017 01 04.
Article
em En
| MEDLINE
| ID: mdl-27903890
ABSTRACT
The 'druggable genome' encompasses several protein families, but only a subset of targets within them have attracted significant research attention and thus have information about them publicly available. The Illuminating the Druggable Genome (IDG) program was initiated in 2014, has the goal of developing experimental techniques and a Knowledge Management Center (KMC) that would collect and organize information about protein targets from four families, representing the most common druggable targets with an emphasis on understudied proteins. Here, we describe two resources developed by the KMC the Target Central Resource Database (TCRD) which collates many heterogeneous gene/protein datasets and Pharos (https//pharos.nih.gov), a multimodal web interface that presents the data from TCRD. We briefly describe the types and sources of data considered by the KMC and then highlight features of the Pharos interface designed to enable intuitive access to the IDG knowledgebase. The aim of Pharos is to encourage 'serendipitous browsing', whereby related, relevant information is made easily discoverable. We conclude by describing two use cases that highlight the utility of Pharos and TCRD.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Farmacogenética
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Genômica
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Bases de Dados Genéticas
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Descoberta de Drogas
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Ferramenta de Busca
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article