Activation of GPR30 stimulates GTP-binding of G&#945;i1 protein to sustain activation of Erk1/2 in inhibition of prostate cancer cell growth and modulates metastatic properties.

Lau, Kin-Mang; Ma, Fanny Man-Ting; Xia, Jenny Tian; Chan, Queeny Kwan Yi; Ng, Chi-Fai; To, Ka-Fai

Activation of GPR30 stimulates GTP-binding of Gαi1 protein to sustain activation of Erk1/2 in inhibition of prostate cancer cell growth and modulates metastatic properties.

Lau, Kin-Mang; Ma, Fanny Man-Ting; Xia, Jenny Tian; Chan, Queeny Kwan Yi; Ng, Chi-Fai; To, Ka-Fai.

Afiliação

Lau KM; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China. Electronic address: kmlau@cuhk.edu.hk.
Ma FM; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
Xia JT; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
Chan QKY; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
Ng CF; Division of Urology, Department of Surgery, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
To KF; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China. Electronic address: kfto@cuhk.edu.hk.

Exp Cell Res ; 350(1): 199-209, 2017 Jan 01.

Article em En | MEDLINE | ID: mdl-27908592

Assuntos

Subunidades alfa Gi-Go de Proteínas de Ligação ao GTP/metabolismo; Sistema de Sinalização das MAP Quinases/fisiologia; Receptores de Estrogênio/metabolismo; Receptores Acoplados a Proteínas G/metabolismo; Adenilil Ciclases/metabolismo; Ciclo Celular/fisiologia; Proliferação de Células/fisiologia; Estrogênios/metabolismo; Humanos; Masculino; Proteína Quinase 1 Ativada por Mitógeno/metabolismo; Neoplasias da Próstata/metabolismo; Neoplasias da Próstata/patologia

Palavras-chave

G protein-coupled estrogen receptor; G-1; GPER; Invasion; Migration

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Estrogênio / Subunidades alfa Gi-Go de Proteínas de Ligação ao GTP / Sistema de Sinalização das MAP Quinases / Receptores Acoplados a Proteínas G Limite: Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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