A functional nanocarrier that copenetrates extracellular matrix and multiple layers of tumor cells for sequential and deep tumor autophagy inhibitor and chemotherapeutic delivery.

Wang, Yang; Qiu, Yue; Yin, Sheng; Zhang, Li; Shi, Kairong; Gao, Huile; Zhang, Zhirong; He, Qin

Wang, Yang; Qiu, Yue; Yin, Sheng; Zhang, Li; Shi, Kairong; Gao, Huile; Zhang, Zhirong; He, Qin.

Afiliação

Wang Y; a Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of education, West China School of Pharmacy, and State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University , Chengdu , China.
Qiu Y; a Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of education, West China School of Pharmacy, and State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University , Chengdu , China.
Yin S; a Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of education, West China School of Pharmacy, and State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University , Chengdu , China.
Zhang L; a Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of education, West China School of Pharmacy, and State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University , Chengdu , China.
Shi K; a Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of education, West China School of Pharmacy, and State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University , Chengdu , China.
Gao H; a Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of education, West China School of Pharmacy, and State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University , Chengdu , China.
Zhang Z; a Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of education, West China School of Pharmacy, and State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University , Chengdu , China.
He Q; a Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of education, West China School of Pharmacy, and State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University , Chengdu , China.

Autophagy ; 13(2): 359-370, 2017 Feb.

Article em En | MEDLINE | ID: mdl-27911136

Assuntos

Adenina/análogos & derivados; Antineoplásicos/farmacologia; Autofagia/efeitos dos fármacos; Portadores de Fármacos/química; Sistemas de Liberação de Medicamentos; Matriz Extracelular/metabolismo; Nanopartículas/química; Adenina/farmacologia; Animais; Linhagem Celular Tumoral; Doxorrubicina/farmacologia; Matriz Extracelular/efeitos dos fármacos; Gelatina/química; Humanos; Células MCF-7; Melanoma Experimental/patologia; Camundongos Endogâmicos C57BL; Tamanho da Partícula; Esferoides Celulares/efeitos dos fármacos; Esferoides Celulares/patologia; Distribuição Tecidual/efeitos dos fármacos

Palavras-chave

autophagy inhibition; deep tumor penetration; multidrug delivery; multilayers tumor cells crossing; multistage size changeable nanocarrier

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Portadores de Fármacos / Adenina / Sistemas de Liberação de Medicamentos / Matriz Extracelular / Nanopartículas / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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