Search for new potential anticonvulsants with anxiolytic and antidepressant properties among derivatives of 4,4-diphenylpyrrolidin-2-one.

Malawska, Katarzyna; Rak, Aleksandra; Gryzlo, Beata; Salat, Kinga; Michalowska, Malgorzata; Zmudzka, Elzbieta; Lodarski, Krzysztof; Malawska, Barbara; Kulig, Katarzyna

Malawska, Katarzyna; Rak, Aleksandra; Gryzlo, Beata; Salat, Kinga; Michalowska, Malgorzata; Zmudzka, Elzbieta; Lodarski, Krzysztof; Malawska, Barbara; Kulig, Katarzyna.

Afiliação

Malawska K; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Kraków, Poland.
Rak A; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Kraków, Poland.
Gryzlo B; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Kraków, Poland.
Salat K; Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Kraków, Poland.
Michalowska M; Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Kraków, Poland; Department of Pharmacodynamics, Medical University of Bialystok, Mickiewicza 2C St., 15-222 Bialystok, Poland.
Zmudzka E; Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Kraków, Poland.
Lodarski K; Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Kraków, Poland.
Malawska B; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Kraków, Poland. Electronic address: mfmalaws@cyf-kr.edu.pl.
Kulig K; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Kraków, Poland.

Pharmacol Rep ; 69(1): 105-111, 2017 Feb.

Article em En | MEDLINE | ID: mdl-27915183

Assuntos

Ansiolíticos/química; Anticonvulsivantes/química; Antidepressivos/química; Piperazinas/química; Animais; Ansiolíticos/uso terapêutico; Anticonvulsivantes/uso terapêutico; Antidepressivos/uso terapêutico; Relação Dose-Resposta a Droga; Eletrochoque/efeitos adversos; Masculino; Bases de Mannich/química; Bases de Mannich/uso terapêutico; Camundongos; Pentilenotetrazol/toxicidade; Piperazinas/uso terapêutico; Convulsões/induzido quimicamente; Convulsões/tratamento farmacológico; Relação Estrutura-Atividade

Palavras-chave

Antidepressant-like activity; Anxiolytic-like activity; MES test; Substituted pyrrolidin-2-one derivatives; scPTZ test

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperazinas / Ansiolíticos / Anticonvulsivantes / Antidepressivos Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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