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Clinical implications of Mycobacterium chimaera detection in thermoregulatory devices used for extracorporeal membrane oxygenation (ECMO), Germany, 2015 to 2016.
Trudzinski, Franziska C; Schlotthauer, Uwe; Kamp, Annegret; Hennemann, Kai; Muellenbach, Ralf M; Reischl, Udo; Gärtner, Barbara; Wilkens, Heinrike; Bals, Robert; Herrmann, Mathias; Lepper, Philipp M; Becker, Sören L.
Afiliação
  • Trudzinski FC; Department of Medicine V - Pneumology, Allergology and Critical Care Medicine, ECLS Center Saar, Saarland University, Homburg/Saar, Germany.
  • Schlotthauer U; Institute of Medical Microbiology and Hygiene, Saarland University, Homburg/Saar, Germany.
  • Kamp A; Department of Medicine V - Pneumology, Allergology and Critical Care Medicine, ECLS Center Saar, Saarland University, Homburg/Saar, Germany.
  • Hennemann K; Department of Thoracic and Cardiovascular Surgery, Saarland University, Homburg/Saar, Germany.
  • Muellenbach RM; Department of Anaesthesiology and Critical Care, Campus Kassel of the University Hospital of Southampton, Kassel, Germany.
  • Reischl U; Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, University of Regensburg, Regensburg, Germany.
  • Gärtner B; Institute of Medical Microbiology and Hygiene, Saarland University, Homburg/Saar, Germany.
  • Wilkens H; Department of Medicine V - Pneumology, Allergology and Critical Care Medicine, ECLS Center Saar, Saarland University, Homburg/Saar, Germany.
  • Bals R; Department of Medicine V - Pneumology, Allergology and Critical Care Medicine, ECLS Center Saar, Saarland University, Homburg/Saar, Germany.
  • Herrmann M; Institute of Medical Microbiology and Hygiene, Saarland University, Homburg/Saar, Germany.
  • Lepper PM; Faculty of Medicine, University of Münster, Münster, Germany.
  • Becker SL; Department of Medicine V - Pneumology, Allergology and Critical Care Medicine, ECLS Center Saar, Saarland University, Homburg/Saar, Germany.
Euro Surveill ; 21(46)2016 Nov 17.
Article em En | MEDLINE | ID: mdl-27918254
ABSTRACT
Mycobacterium chimaera, a non-tuberculous mycobacterium, was recently identified as causative agent of deep-seated infections in patients who had previously undergone open-chest cardiac surgery. Outbreak investigations suggested an aerosol-borne pathogen transmission originating from water contained in heater-cooler units (HCUs) used during cardiac surgery. Similar thermoregulatory devices are used for extracorporeal membrane oxygenation (ECMO) and M. chimaera might also be detectable in ECMO treatment settings. We performed a prospective microbiological study investigating the occurrence of M. chimaera in water from ECMO systems and in environmental samples, and a retrospective clinical review of possible ECMO-related mycobacterial infections among patients in a pneumological intensive care unit. We detected M. chimaera in 9 of 18 water samples from 10 different thermoregulatory ECMO devices; no mycobacteria were found in the nine room air samples and other environmental samples. Among 118 ECMO patients, 76 had bronchial specimens analysed for mycobacteria and M. chimaera was found in three individuals without signs of mycobacterial infection at the time of sampling. We conclude that M. chimaera can be detected in water samples from ECMO-associated thermoregulatory devices and might potentially pose patients at risk of infection. Further research is warranted to elucidate the clinical significance of M. chimaera in ECMO treatment settings.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções Oportunistas / Oxigenação por Membrana Extracorpórea / Infecção Hospitalar / Mycobacterium / Micobactérias não Tuberculosas / Infecções por Mycobacterium não Tuberculosas Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Humans / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções Oportunistas / Oxigenação por Membrana Extracorpórea / Infecção Hospitalar / Mycobacterium / Micobactérias não Tuberculosas / Infecções por Mycobacterium não Tuberculosas Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Humans / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article