Developmental expression of Ca++/Mg++-dependent endonuclease activity in rat granulosa and luteal cells.
Endocrinology
; 125(4): 2218-20, 1989 Oct.
Article
em En
| MEDLINE
| ID: mdl-2791987
ABSTRACT
A Ca++/Mg++-sensitive endonuclease has been associated with programmed cell death in a variety of endocrine and non-endocrine dependent tissues. In view of the remarkable similarity of the process of the regression of the corpus luteum and other models of programmed cell death, we studied the occurrance of this endonuclease activity in granulosa cells at different developmental states and the corpus luteum. Our results show that while undifferentiated granulosa cells do not express this endonuclease activity, treatment with pregnant mares serum gonadotropin results in a rapid increase in endonuclease activity that is maintained following ovulation and luteinization of granulosa cells.
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Base de dados:
MEDLINE
Assunto principal:
Corpo Lúteo
/
Endodesoxirribonucleases
/
Células da Granulosa
Limite:
Animals
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article