Ischemic myopathy revealing systemic calciphylaxis.
Muscle Nerve
; 56(3): 529-533, 2017 09.
Article
em En
| MEDLINE
| ID: mdl-27935078
ABSTRACT
INTRODUCTION:
Patients with renal failure who are being treated with dialysis frequently develop neuromuscular manifestations. Renal failure-associated calciphylaxis, also termed calcific uremic arteriolopathy (CUA), is a life-threatening condition usually observed in patients with end-stage renal disease on chronic dialysis or after renal transplantation.METHODS:
We describe a hemodialyzed patient who presented with rapidly progressive unexplained systemic vasculopathy, muscle atrophy, and proximal weakness, that unexpectedly proved to be caused by calciphylaxis.RESULTS:
Quadriceps muscle biopsy disclosed diffuse vascular calcific deposits on medium- and small-sized vessels, characteristic of CUA. Other changes included ischemic myopathy, focal intracellular calcium accumulation within myofibers, and calcium deposits in endomysial capillaries associated with marked complement activation and C5b9 formation.CONCLUSION:
There are only a few descriptions of muscle involvement in the context of CUA, a condition with a prognosis that depends on early diagnosis and treatment. This report underscores the usefulness of muscle biopsy in the diagnosis of systemic calciphylaxis. Muscle Nerve 56 529-533, 2017.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Calciofilaxia
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Vasculite Sistêmica
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Isquemia
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Doenças Musculares
Tipo de estudo:
Prognostic_studies
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Screening_studies
Limite:
Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article