Five New C19 -Diterpenoid Alkaloids from Delphinium tianshanicum W.T.Wang.
Chem Biodivers
; 14(4)2017 Apr.
Article
em En
| MEDLINE
| ID: mdl-27936494
ABSTRACT
Five new diterpenoid alkaloids, tianshanitines A-E (1 - 5), along with ten known compounds (6 - 15), were isolated from the EtOH extracts of the whole plant of Delphinium tianshanicum W.T.Wang. Their structures were determined based on extensive spectroscopic analyses, including 1D- and 2D-NMR, HR-ESI-MS, and the structure of tianshanitine C (3) was confirmed by X-ray diffraction analysis. Tianshanitine A (1) is the first example of natural diterpenoid alkaloid containing a benzoyl group at C(1) position. Tianshanitine B (2) is a rare natural diterpenoid alkaloid bearing a OH group at C(16) position. Compounds 1 - 5, 6, 8, 10, 12 and 14 were evaluated for cytotoxicity against HCT116, MCF-7 and HepG2 human cancer cell lines.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Delphinium
/
Diterpenos
/
Alcaloides
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article