Neutrophil migration in inflammation: intercellular signal relay and crosstalk.
Curr Opin Immunol
; 44: 34-42, 2017 Feb.
Article
em En
| MEDLINE
| ID: mdl-27951434
ABSTRACT
Neutrophils are innate effector cells armed with a potent machinery to combat damage and infection within tissues. Their ability to rapidly respond to danger signals and mobilise is crucial to their role. After extravasation, neutrophil populations often exhibit swarming behaviour. Swarming occurs in distinct phases and is coordinated via inter-neutrophil signal relay in the form of small molecule mediators. Neutrophils also engage in multi-dimensional crosstalk with tissue-resident cells and incoming leukocytes in the inflammatory milieu. The complexity of neutrophil crosstalk with other innate immune cells mirrors that of the adaptive immune system, with rudimentary features of 'priming' and 'licensing'. We review recent findings relating to the migration and intercellular crosstalks of neutrophils in the initiation and resolution of inflammation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Movimento Celular
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Comunicação Parácrina
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Imunidade Inata
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Inflamação
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Neutrófilos
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article