Polyamine-trypanothione pathway: an update.
Future Med Chem
; 9(1): 61-77, 2017 01.
Article
em En
| MEDLINE
| ID: mdl-27957878
ABSTRACT
In trypanosomatids, polyamine and trypanothione pathways can be considered as a whole unique metabolism, where most enzymes are essential for parasitic survival and infectivity. Leishmania parasites and all the other members of the Trypanosomatids family depend on polyamines for growth and survival the enzymes involved in the synthesis and utilization of spermidine and trypanothione, i.e., arginase, ornithine decarboxylase, S-adenosylmethionine decarboxylase, spermidine synthase and in particular trypanothione synthetase-amidase, trypanothione reductase and tryparedoxin-dependent peroxidase are promising targets for drug development. This review deals with recent structure-based studies on these enzymes, aimed at the discovery of inhibitors of this pathway.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Poliaminas
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Leishmaniose
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Espermidina
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Inibidores Enzimáticos
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Glutationa
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Antiprotozoários
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article