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Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors.
Huang, Xiumei; Motea, Edward A; Moore, Zachary R; Yao, Jun; Dong, Ying; Chakrabarti, Gaurab; Kilgore, Jessica A; Silvers, Molly A; Patidar, Praveen L; Cholka, Agnieszka; Fattah, Farjana; Cha, Yoonjeong; Anderson, Glenda G; Kusko, Rebecca; Peyton, Michael; Yan, Jingsheng; Xie, Xian-Jin; Sarode, Venetia; Williams, Noelle S; Minna, John D; Beg, Muhammad; Gerber, David E; Bey, Erik A; Boothman, David A.
Afiliação
  • Huang X; Departments of Pharmacology and Radiation Oncology, Simmons Comprehensive Cancer Center (SCCC), UT Southwestern Medical Center (UTSW), Dallas, TX 75390, USA.
  • Motea EA; Departments of Pharmacology and Radiation Oncology, Simmons Comprehensive Cancer Center (SCCC), UT Southwestern Medical Center (UTSW), Dallas, TX 75390, USA.
  • Moore ZR; Departments of Pharmacology and Radiation Oncology, Simmons Comprehensive Cancer Center (SCCC), UT Southwestern Medical Center (UTSW), Dallas, TX 75390, USA.
  • Yao J; Departments of Pharmacology and Radiation Oncology, Simmons Comprehensive Cancer Center (SCCC), UT Southwestern Medical Center (UTSW), Dallas, TX 75390, USA.
  • Dong Y; Departments of Pharmacology and Radiation Oncology, Simmons Comprehensive Cancer Center (SCCC), UT Southwestern Medical Center (UTSW), Dallas, TX 75390, USA.
  • Chakrabarti G; Departments of Pharmacology and Radiation Oncology, Simmons Comprehensive Cancer Center (SCCC), UT Southwestern Medical Center (UTSW), Dallas, TX 75390, USA.
  • Kilgore JA; Department of Biochemistry, SCCC, UTSW, Dallas, TX 75390, USA.
  • Silvers MA; Departments of Pharmacology and Radiation Oncology, Simmons Comprehensive Cancer Center (SCCC), UT Southwestern Medical Center (UTSW), Dallas, TX 75390, USA.
  • Patidar PL; Departments of Pharmacology and Radiation Oncology, Simmons Comprehensive Cancer Center (SCCC), UT Southwestern Medical Center (UTSW), Dallas, TX 75390, USA.
  • Cholka A; Departments of Pharmacology and Radiation Oncology, Simmons Comprehensive Cancer Center (SCCC), UT Southwestern Medical Center (UTSW), Dallas, TX 75390, USA.
  • Fattah F; Departments of Pharmacology and Radiation Oncology, Simmons Comprehensive Cancer Center (SCCC), UT Southwestern Medical Center (UTSW), Dallas, TX 75390, USA.
  • Cha Y; Immuneering Corporation, One Broadway 14th Floor, Cambridge, MA 02142, USA.
  • Anderson GG; 5Degrees Bio., Inc., 111 North Market Street #300, San Jose, CA 95113, USA.
  • Kusko R; Immuneering Corporation, One Broadway 14th Floor, Cambridge, MA 02142, USA.
  • Peyton M; Department of Internal Medicine, Division of Hematology-Oncology, UTSW, Dallas, TX 75390, USA.
  • Yan J; Department of Biostatistics, UTSW, Dallas, TX 75390, USA.
  • Xie XJ; Department of Biostatistics, UTSW, Dallas, TX 75390, USA.
  • Sarode V; Department of Pathology, UTSW, Dallas, TX 75390, USA.
  • Williams NS; Department of Biochemistry, SCCC, UTSW, Dallas, TX 75390, USA.
  • Minna JD; Department of Internal Medicine, Division of Hematology-Oncology, UTSW, Dallas, TX 75390, USA.
  • Beg M; Department of Internal Medicine, Division of Hematology-Oncology, UTSW, Dallas, TX 75390, USA.
  • Gerber DE; Department of Internal Medicine, Division of Hematology-Oncology, UTSW, Dallas, TX 75390, USA.
  • Bey EA; Department of Pharmaceutical Sciences, West Virginia University Cancer Institute, Morgantown, WV 26506, USA. Electronic address: erik.bey@hsc.wvu.edu.
  • Boothman DA; Departments of Pharmacology and Radiation Oncology, Simmons Comprehensive Cancer Center (SCCC), UT Southwestern Medical Center (UTSW), Dallas, TX 75390, USA. Electronic address: david.boothman@utsouthwestern.edu.
Cancer Cell ; 30(6): 940-952, 2016 Dec 12.
Article em En | MEDLINE | ID: mdl-27960087
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Naftoquinonas / NAD(P)H Desidrogenase (Quinona) / Carcinoma Pulmonar de Células não Pequenas / Inibidores de Poli(ADP-Ribose) Polimerases / Neoplasias Pulmonares Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Naftoquinonas / NAD(P)H Desidrogenase (Quinona) / Carcinoma Pulmonar de Células não Pequenas / Inibidores de Poli(ADP-Ribose) Polimerases / Neoplasias Pulmonares Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article