[Prediction of microRNA-296-5p target genes and its application in lung development].
Zhongguo Dang Dai Er Ke Za Zhi
; 18(12): 1302-1307, 2016 Dec.
Article
em Zh
| MEDLINE
| ID: mdl-27974127
ABSTRACT
OBJECTIVE:
To predict the target genes of rno-microRNA-296-5p (miR-296) using bioinformatics software and databases, and to provide a theoretical basis for further studies of biological effects of miR-296 in fetal lung development.METHODS:
PubMed and Google were used to search for all reported literature on miR-296. The miRBase database was used to determine the sequence and evolutionary conservatism of miR-296. The TargetScans database was used to predict the target genes of miR-296. The DAVID Bioinformatics Resources 6.8 database was used for the functional enrichment analysis of the target genes. The KEGG database was used to analyze the signaling pathways of target genes.RESULTS:
miR-296 was reported to play important roles in many biological processes and have a high degree of sequence conservation among species. The target genes of miR-296 were involved in biological processes, cell components, and molecular function. Those target genes were significantly enriched in the mitogen-activated protein kinase signaling pathway, Wnt signaling pathway, and transforming growth factor-ß signaling pathway (p<0.05).CONCLUSIONS:
The bioinformatics analysis of the target genes of miR-296 provides a basis for studying biological effects and mechanism of action of miR-296 in lung development.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Biologia Computacional
/
MicroRNAs
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Pulmão
Tipo de estudo:
Prognostic_studies
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Risk_factors_studies
Limite:
Animals
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Humans
Idioma:
Zh
Ano de publicação:
2016
Tipo de documento:
Article