Functional and structural characterisation of a bacterial O-methyltransferase and factors determining regioselectivity.

Siegrist, Jutta; Netzer, Julia; Mordhorst, Silja; Karst, Lukas; Gerhardt, Stefan; Einsle, Oliver; Richter, Michael; Andexer, Jennifer N

Siegrist, Jutta; Netzer, Julia; Mordhorst, Silja; Karst, Lukas; Gerhardt, Stefan; Einsle, Oliver; Richter, Michael; Andexer, Jennifer N.

Afiliação

Siegrist J; Institute of Pharmaceutical Sciences, Albert-Ludwigs-University Freiburg, Germany.
Netzer J; Institute of Biochemistry, Albert-Ludwigs-University Freiburg, Germany.
Mordhorst S; Institute of Pharmaceutical Sciences, Albert-Ludwigs-University Freiburg, Germany.
Karst L; Institute of Pharmaceutical Sciences, Albert-Ludwigs-University Freiburg, Germany.
Gerhardt S; Institute of Biochemistry, Albert-Ludwigs-University Freiburg, Germany.
Einsle O; Institute of Biochemistry, Albert-Ludwigs-University Freiburg, Germany.
Richter M; BIOSS Centre for Biological Signalling Studies, Freiburg, Germany.
Andexer JN; Bio-, Electro- and Chemocatalysis BioCat, Straubing Branch, Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Straubing, Germany.

FEBS Lett ; 591(2): 312-321, 2017 01.

Article em En | MEDLINE | ID: mdl-27990630

Assuntos

Proteínas de Bactérias/química; Proteínas de Bactérias/metabolismo; Catecol O-Metiltransferase/química; Catecol O-Metiltransferase/metabolismo; Myxococcus/enzimologia; Domínio Catalítico; Cromatografia Líquida de Alta Pressão; Modelos Moleculares; Estereoisomerismo; Especificidade por Substrato

Palavras-chave

SafC; biocatalysis; catechol; catechol-O-methyltransferase; methylation; structure-function relationship

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Catecol O-Metiltransferase / Myxococcus Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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