Construction of Chiral Tetraorganosilicons by Tandem Desymmetrization of Silacyclobutanes/Intermolecular Dehydrogenative Silylation.

Zhang, Qing-Wei; An, Kun; Liu, Li-Chuan; Zhang, Qi; Guo, Huifang; He, Wei

Zhang, Qing-Wei; An, Kun; Liu, Li-Chuan; Zhang, Qi; Guo, Huifang; He, Wei.

Afiliação

Zhang QW; School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
An K; School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
Liu LC; School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
Zhang Q; School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
Guo H; School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
He W; School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.

Angew Chem Int Ed Engl ; 56(4): 1125-1129, 2017 01 19.

Article em En | MEDLINE | ID: mdl-27990736

ABSTRACT

ABSTRACT

We report a method to construct chiral tetraorganosilicons by tandem silacyclobutane (SCB) desymmetrization-dehydrogenative silylations. A wide array of dibenzosiloles with stereogenic quaternary silicon centers were obtained in good yields and enantioselectivities up to 93 % ee. Chiral TMS-segphos was found to be a superior ligand in terms of reactivity and enantioselectivity.

Palavras-chave

dibenzosiloles; enantioselectivity; silacyclobutanes; tetraorganosilicons

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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