Pharmacological Blockade of the Chemokine Receptor CCR1 Protects Mice from Systemic Candidiasis of Hematogenous Origin.
Antimicrob Agents Chemother
; 61(3)2017 03.
Article
em En
| MEDLINE
| ID: mdl-27993850
ABSTRACT
Systemic candidiasis is a leading cause of nosocomial bloodstream infection with a high mortality rate despite treatment. Immune-based strategies are needed to improve outcomes. We previously reported that genetic deficiency in the chemokine receptor CCR1 improves survival and ameliorates tissue damage in Candida-infected mice. Here, we found that treatment of immunocompetent Candida-infected mice with the CCR1-selective antagonist BL5923 improves survival, decreases the kidney fungal burden, and protects from renal tissue injury.
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Base de dados:
MEDLINE
Assunto principal:
Piperazinas
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Candida albicans
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Receptores CCR1
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Candidíase Invasiva
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Injúria Renal Aguda
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Hemorragia
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article