Cytoglobosins H and I, New Antiproliferative Cytochalasans from Deep-Sea-Derived Fungus Chaetomium globosum.
Mar Drugs
; 14(12)2016 Dec 20.
Article
em En
| MEDLINE
| ID: mdl-27999388
ABSTRACT
Cytoglobosins H (1) and I (2), together with seven known cytochalasan alkaloids (3-9), were isolated from the deep-sea-derived fungus Chaetomium globosum. The structures of new compounds 1 and 2 were elucidated by extensive 1D and 2D NMR and mass spectroscopic data. All the compounds were evaluated for their antiproliferative activities against MDA-MB-231 human breast cancer cells, LNCaP human prostate cancer cells, and B16F10 mouse melanoma cells. Compound 6 showed significant antiproliferative activity against LNCaP and B16F10 cell lines with IC50 values of 0.62 and 2.78 µM, respectively. Further testing confirmed that compound 6 inhibited the growth of LNCaP cells by inducing apoptosis.
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Base de dados:
MEDLINE
Assunto principal:
Chaetomium
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Alcaloides Indólicos
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Antineoplásicos
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article