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Discovery of N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia.
Debenham, John S; Madsen-Duggan, Christina; Clements, Matthew J; Walsh, Thomas F; Kuethe, Jeffrey T; Reibarkh, Mikhail; Salowe, Scott P; Sonatore, Lisa M; Hajdu, Richard; Milligan, James A; Visco, Denise M; Zhou, Dan; Lingham, Russell B; Stickens, Dominique; DeMartino, Julie A; Tong, Xinchun; Wolff, Michael; Pang, Jianmei; Miller, Randy R; Sherer, Edward C; Hale, Jeffrey J.
Afiliação
  • Debenham JS; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Madsen-Duggan C; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Clements MJ; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Walsh TF; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Kuethe JT; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Reibarkh M; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Salowe SP; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Sonatore LM; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Hajdu R; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Milligan JA; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Visco DM; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Zhou D; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Lingham RB; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Stickens D; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • DeMartino JA; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Tong X; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Wolff M; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Pang J; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Miller RR; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Sherer EC; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Hale JJ; Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
J Med Chem ; 59(24): 11039-11049, 2016 12 22.
Article em En | MEDLINE | ID: mdl-28002958
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridazinas / Pirimidinas / Inibidores Enzimáticos / Descoberta de Drogas / Prolina Dioxigenases do Fator Induzível por Hipóxia / Anemia Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridazinas / Pirimidinas / Inibidores Enzimáticos / Descoberta de Drogas / Prolina Dioxigenases do Fator Induzível por Hipóxia / Anemia Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article