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HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation.
Myant, Kevin B; Cammareri, Patrizia; Hodder, Michael C; Wills, Jimi; Von Kriegsheim, Alex; Gyorffy, Balázs; Rashid, Mamun; Polo, Simona; Maspero, Elena; Vaughan, Lynsey; Gurung, Basanta; Barry, Evan; Malliri, Angeliki; Camargo, Fernando; Adams, David J; Iavarone, Antonio; Lasorella, Anna; Sansom, Owen J.
Afiliação
  • Myant KB; Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, UK kevin.myant@igmm.ed.ac.uk o.sansom@beatson.gla.ac.uk.
  • Cammareri P; Cancer Research UK Edinburgh Centre, The Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.
  • Hodder MC; Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, UK.
  • Wills J; Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, UK.
  • Von Kriegsheim A; Cancer Research UK Edinburgh Centre, The Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.
  • Gyorffy B; Cancer Research UK Edinburgh Centre, The Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.
  • Rashid M; MTA TTK Lendület Cancer Biomarker Research Group, Budapest, Hungary.
  • Polo S; 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary.
  • Maspero E; Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
  • Vaughan L; IFOM, The FIRC Institute for Molecular Oncology, Milano, Italy.
  • Gurung B; IFOM, The FIRC Institute for Molecular Oncology, Milano, Italy.
  • Barry E; Cancer Research UK Manchester Institute, The University of Manchester, Withington, Manchester, UK.
  • Malliri A; Boston Children's Hospital, Boston, MA, USA.
  • Camargo F; Boston Children's Hospital, Boston, MA, USA.
  • Adams DJ; Cancer Research UK Manchester Institute, The University of Manchester, Withington, Manchester, UK.
  • Iavarone A; Boston Children's Hospital, Boston, MA, USA.
  • Lasorella A; Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
  • Sansom OJ; Departments of Neurology and Pathology, Institute for Cancer Genetics, Irving Comprehensive Research Center, New York, NY, USA.
EMBO Mol Med ; 9(2): 181-197, 2017 02.
Article em En | MEDLINE | ID: mdl-28003334
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Neoplasias Colorretais / Transdução de Sinais / Genes Supressores de Tumor / Proteínas Proto-Oncogênicas c-myc / Ubiquitina-Proteína Ligases / Carcinogênese Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Neoplasias Colorretais / Transdução de Sinais / Genes Supressores de Tumor / Proteínas Proto-Oncogênicas c-myc / Ubiquitina-Proteína Ligases / Carcinogênese Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article