Angiodysplasia in embryo lacking protein arginine methyltransferase 1 in vascular endothelial cells.
J Biochem
; 161(3): 255-258, 2017 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-28003433
ABSTRACT
Protein arginine methyltransferase 1 (PRMT1) is involved in multiple cellular functions including proliferation and differentiation. Although PRMT1 is expressed in vascular endothelial cells (ECs), which are responsible for angiogenesis during embryonic development, its role has remained elusive. In this study, we generated endothelial-specific prmt1-knockout (Prmt1-ECKO) mice, and found that they died before embryonic day 15. The superficial temporal arteries in these embryos were poorly perfused with blood, and whole-mount 3D imaging revealed dilated and segmentalized luminal structures in Prmt1-ECKO fetuses in comparison with those of controls. Our findings provide evidence that PRMT1 is important for embryonic vascular formation.
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Base de dados:
MEDLINE
Assunto principal:
Proteína-Arginina N-Metiltransferases
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Angiodisplasia
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Células Endoteliais
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article