In Vivo Ischemia Detection by Luminescent Nanothermometers.
Adv Healthc Mater
; 6(4)2017 Feb.
Article
em En
| MEDLINE
| ID: mdl-28009096
ABSTRACT
There is an urgent need to develop new diagnosis tools for real in vivo detection of first stages of ischemia for the early treatment of cardiovascular diseases and accidents. However, traditional approaches show low sensitivity and a limited penetration into tissues, so they are only applicable for the detection of surface lesions. Here, it is shown how the superior thermal sensing capabilities of near infrared-emitting quantum dots (NIR-QDs) can be efficiently used for in vivo detection of subcutaneous ischemic tissues. In particular, NIR-QDs make possible ischemia detection by high penetration transient thermometry studies in a murine ischemic hindlimb model. NIR-QDs nanothermometers are able to identify ischemic tissues by means of their faster thermal dynamics. In addition, they have shown to be capable of monitoring both the revascularization and damage recovery processes of ischemic tissues. This work demonstrates the applicability of fluorescence nanothermometry for ischemia detection and treatment, as well as a tool for early diagnosis of cardiovascular disease.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Termômetros
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Pontos Quânticos
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Termometria
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Raios Infravermelhos
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Isquemia
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Medições Luminescentes
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article