ß2-adrenergic receptor control of endosomal PTH receptor signaling via Gßγ.
Nat Chem Biol
; 13(3): 259-261, 2017 03.
Article
em En
| MEDLINE
| ID: mdl-28024151
ABSTRACT
Cells express several G-protein-coupled receptors (GPCRs) at their surfaces, transmitting simultaneous extracellular hormonal and chemical signals into cells. A comprehensive understanding of mechanisms underlying the integrated signaling response induced by distinct GPCRs is thus required. Here we found that the ß2-adrenergic receptor, which induces a short cAMP response, prolongs nuclear cAMP and protein kinase A (PKA) activation by promoting endosomal cAMP production in parathyroid hormone (PTH) receptor signaling through the stimulatory action of G protein Gßγ subunits on adenylate cyclase type 2.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Endossomos
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Transdução de Sinais
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Receptores Adrenérgicos beta 2
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Subunidades beta da Proteína de Ligação ao GTP
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Subunidades gama da Proteína de Ligação ao GTP
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Receptor Tipo 1 de Hormônio Paratireóideo
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article