Guidance to rational use of pharmaceuticals in gallbladder sarcomatoid carcinoma using patient-derived cancer cells and whole exome sequencing.

Feng, Feiling; Cheng, Qingbao; Yang, Liang; Zhang, Dadong; Ji, Shunlong; Zhang, Qiangzu; Lin, Yihui; Li, Fugen; Xiong, Lei; Liu, Chen; Jiang, Xiaoqing

Feng, Feiling; Cheng, Qingbao; Yang, Liang; Zhang, Dadong; Ji, Shunlong; Zhang, Qiangzu; Lin, Yihui; Li, Fugen; Xiong, Lei; Liu, Chen; Jiang, Xiaoqing.

Afiliação

Feng F; Department of Biliary I, Third Affiliated Hospital of PLA Second Military Medical University, Shanghai, China.
Cheng Q; Department of Biliary I, Third Affiliated Hospital of PLA Second Military Medical University, Shanghai, China.
Yang L; Department of Biliary I, Third Affiliated Hospital of PLA Second Military Medical University, Shanghai, China.
Zhang D; Division of Translational Medicine, 3D Medicines Corporation, Shanghai, China.
Ji S; Changhai Hospital, The Second Military Medical University, Shanghai, China.
Zhang Q; Division of Translational Medicine, 3D Medicines Corporation, Shanghai, China.
Lin Y; Division of Translational Medicine, 3D Medicines Corporation, Shanghai, China.
Li F; Division of Translational Medicine, 3D Medicines Corporation, Shanghai, China.
Xiong L; Division of Translational Medicine, 3D Medicines Corporation, Shanghai, China.
Liu C; Division of Translational Medicine, 3D Medicines Corporation, Shanghai, China.
Jiang X; Department of Biliary I, Third Affiliated Hospital of PLA Second Military Medical University, Shanghai, China.

Oncotarget ; 8(3): 5349-5360, 2017 Jan 17.

Article em En | MEDLINE | ID: mdl-28029662

Assuntos

Antineoplásicos/farmacologia; Carcinoma/genética; Ensaios de Seleção de Medicamentos Antitumorais/métodos; Neoplasias da Vesícula Biliar/genética; Idoso; Biomarcadores Tumorais/genética; Carcinoma/patologia; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Neoplasias da Vesícula Biliar/patologia; Humanos; Masculino; Sequenciamento do Exoma

Palavras-chave

PIK3CA amplification; drug sensitivity; gallbladder sarcomatoid carcinoma (GSC); patient-derived cancer cell (PDC); whole exome sequencing (WES)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ensaios de Seleção de Medicamentos Antitumorais / Carcinoma / Neoplasias da Vesícula Biliar / Antineoplásicos Tipo de estudo: Guideline / Prognostic_studies Limite: Aged / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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