Neonatal Hypoxia Results in Peripheral Nerve Abnormalities.
Am J Pathol
; 187(2): 245-251, 2017 Feb.
Article
em En
| MEDLINE
| ID: mdl-28062081
ABSTRACT
Although the adverse effects of neonatal hypoxia associated with premature birth on the central nervous system are well known, the contribution of hypoxic damage to the peripheral nervous system (PNS) has not been addressed. We demonstrate that neonatal hypoxia results in hypomyelination and delayed axonal sorting in mice leading to electrophysiological and motor deficits that persist into adulthood. These findings support a potential role for PNS hypoxic damage in the motor impairment that results from premature birth and suggest that therapies designed to protect the PNS may provide clinical benefit.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nervo Isquiático
/
Axônios
/
Hipóxia
/
Bainha de Mielina
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article