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Nanocaged platforms: modification, drug delivery and nanotoxicity. Opening synthetic cages to release the tiger.
Karimi, Mahdi; Zangabad, Parham Sahandi; Mehdizadeh, Fatemeh; Malekzad, Hedieh; Ghasemi, Alireza; Bahrami, Sajad; Zare, Hossein; Moghoofei, Mohsen; Hekmatmanesh, Amin; Hamblin, Michael R.
Afiliação
  • Karimi M; Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
  • Zangabad PS; Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Mehdizadeh F; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • Malekzad H; Research Center for Pharmaceutical Nanotechnology (RCPN), Tabriz University of Medical Science (TUOMS), Tabriz, Iran.
  • Ghasemi A; Advanced Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran University of Medical Sciences, Tehran, Iran.
  • Bahrami S; Department of Materials Science and Engineering, Sharif University of Technology, 11365-9466, Tehran, Iran.
  • Zare H; Nanomedicine Research Association (NRA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
  • Moghoofei M; Department of Applied Chemistry, University of Tabriz, Tabriz, Iran.
  • Hekmatmanesh A; Advanced Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran University of Medical Sciences, Tehran, Iran.
  • Hamblin MR; Faculty of Chemistry, Kharazmi University of Tehran, Tehran, Iran.
Nanoscale ; 9(4): 1356-1392, 2017 Jan 26.
Article em En | MEDLINE | ID: mdl-28067384
Nanocages (NCs) have emerged as a new class of drug-carriers, with a wide range of possibilities in multi-modality medical treatments and theranostics. Nanocages can overcome such limitations as high toxicity caused by anti-cancer chemotherapy or by the nanocarrier itself, due to their unique characteristics. These properties consist of: (1) a high loading-capacity (spacious interior); (2) a porous structure (analogous to openings between the bars of the cage); (3) enabling smart release (a key to unlock the cage); and (4) a low likelihood of unfavorable immune responses (the outside of the cage is safe). In this review, we cover different classes of NC structures such as virus-like particles (VLPs), protein NCs, DNA NCs, supramolecular nanosystems, hybrid metal-organic NCs, gold NCs, carbon-based NCs and silica NCs. Moreover, NC-assisted drug delivery including modification methods, drug immobilization, active targeting, and stimulus-responsive release mechanisms are discussed, highlighting the advantages, disadvantages and challenges. Finally, translation of NCs into clinical applications, and an up-to-date assessment of the nanotoxicology considerations of NCs are presented.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistemas de Liberação de Medicamentos / Nanoestruturas / Nanomedicina Teranóstica Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistemas de Liberação de Medicamentos / Nanoestruturas / Nanomedicina Teranóstica Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article