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Cyanobacteria: photosynthetic factories combining biodiversity, radiation resistance, and genetics to facilitate drug discovery.
Cassier-Chauvat, Corinne; Dive, Vincent; Chauvat, Franck.
Afiliação
  • Cassier-Chauvat C; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ Paris-Sud, Université Paris-Saclay, 91191, Gif-sur-Yvette cedex, France.
  • Dive V; Service d'Ingénierie Moléculaire des Protéines (SIMOPRO), IBITECS, CEA, Université Paris-Saclay, F-91191, Gif-sur-Yvette, France.
  • Chauvat F; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ Paris-Sud, Université Paris-Saclay, 91191, Gif-sur-Yvette cedex, France. franck.chauvat@cea.fr.
Appl Microbiol Biotechnol ; 101(4): 1359-1364, 2017 Feb.
Article em En | MEDLINE | ID: mdl-28083651
Cyanobacteria are ancient, abundant, and widely diverse photosynthetic prokaryotes, which are viewed as promising cell factories for the ecologically responsible production of chemicals. Natural cyanobacteria synthesize a vast array of biologically active (secondary) metabolites with great potential for human health, while a few genetic models can be engineered for the (low level) production of biofuels. Recently, genome sequencing and mining has revealed that natural cyanobacteria have the capacity to produce many more secondary metabolites than have been characterized. The corresponding panoply of enzymes (polyketide synthases and non-ribosomal peptide synthases) of interest for synthetic biology can still be increased through gene manipulations with the tools available for the few genetically manipulable strains. In this review, we propose to exploit the metabolic diversity and radiation resistance of cyanobacteria, and when required the genetics of model strains, for the production and radioactive (14C) labeling of bioactive products, in order to facilitate the screening for new drugs.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fotossíntese / Cianobactérias Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fotossíntese / Cianobactérias Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2017 Tipo de documento: Article