Getting to and through the inner nuclear membrane during herpesvirus nuclear egress.
Curr Opin Cell Biol
; 46: 9-16, 2017 06.
Article
em En
| MEDLINE
| ID: mdl-28086162
ABSTRACT
Herpesviruses, like most DNA viruses, replicate and package their genomes into capsids in the host cell nucleus. Capsids then transit to the cytoplasm in a fascinating process called nuclear egress, which includes several unusual steps:
Movement of capsids from the nuclear interior to the periphery, disruption of the nuclear lamina, capsid budding through the inner nuclear membrane, and fusion of enveloped particles with the outer nuclear membrane. Here, we review recent advances and emerging questions relating to herpesvirus nuclear egress, emphasizing controversies regarding mechanisms for capsid trafficking to the nuclear periphery, and implications of recent structures of the two-subunit, viral nuclear egress complex for the process, particularly at the step of budding through the inner nuclear membrane.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transporte Biológico
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Núcleo Celular
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Herpesviridae
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Membrana Nuclear
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article