Differences in antimicrobial susceptibility of pigmented and unpigmented colonial variants of Mycobacterium avium.
J Clin Microbiol
; 27(11): 2459-65, 1989 Nov.
Article
em En
| MEDLINE
| ID: mdl-2808669
ABSTRACT
Unpigmented colonial variants were isolated from pigmented Mycobacterium avium isolates recovered from patients with acquired immunodeficiency syndrome and the environment. The variants were interconvertible the rate of transition from unpigmented to pigmented type was 4.0 x 10(-5) variants per cell per generation. The unpigmented variants were more tolerant to antibiotics, especially beta-lactams, and Cd2+ and Cu2+ salts than were their pigmented parents. Both pigmented and unpigmented variants of the strains produced beta-lactamase, although beta-lactamase did not appear to be a determinant of beta-lactam susceptibility. Pigmented variants grew more rapidly in a number of commonly used mycobacterial media, were more hydrophobic, and had higher carotenoid contents than their unpigmented segregants.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pigmentos Biológicos
/
Complexo Mycobacterium avium
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Infecção por Mycobacterium avium-intracellulare
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Síndrome da Imunodeficiência Adquirida
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Antibacterianos
Limite:
Humans
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article