Direct control of regulatory T cells by keratinocytes.
Nat Immunol
; 18(3): 334-343, 2017 03.
Article
em En
| MEDLINE
| ID: mdl-28092372
ABSTRACT
Environmental challenges to epithelial cells trigger gene expression changes that elicit context-appropriate immune responses. We found that the chromatin remodeler Mi-2ß controls epidermal homeostasis by regulating the genes involved in keratinocyte and immune-cell activation to maintain an inactive state. Mi-2ß depletion resulted in rapid deployment of both a pro-inflammatory and an immunosuppressive response in the skin. A key target of Mi-2ß in keratinocytes is the pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP). Loss of TSLP receptor (TSLPR) signaling specifically in regulatory T (Treg) cells prevented their activation and permitted rapid progression from a skin pro-inflammatory response to a lethal systemic condition. Thus, in addition to their well-characterized role in pro-inflammatory responses, keratinocytes also directly support immune-suppressive responses that are critical for re-establishing organismal homeostasis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulinas
/
Queratinócitos
/
Citocinas
/
Linfócitos T Reguladores
/
Receptores de Citocinas
/
DNA Helicases
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article