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Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.
Singh, Kawaljit; Okombo, John; Brunschwig, Christel; Ndubi, Ferdinand; Barnard, Linley; Wilkinson, Chad; Njogu, Peter M; Njoroge, Mathew; Laing, Lizahn; Machado, Marta; Prudêncio, Miguel; Reader, Janette; Botha, Mariette; Nondaba, Sindisiwe; Birkholtz, Lyn-Marie; Lauterbach, Sonja; Churchyard, Alisje; Coetzer, Theresa L; Burrows, Jeremy N; Yeates, Clive; Denti, Paolo; Wiesner, Lubbe; Egan, Timothy J; Wittlin, Sergio; Chibale, Kelly.
Afiliação
  • Singh K; Department of Chemistry, University of Cape Town , Rondebosch 7701, South Africa.
  • Okombo J; South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town , Rondebosch 7701, South Africa.
  • Brunschwig C; Department of Chemistry, University of Cape Town , Rondebosch 7701, South Africa.
  • Ndubi F; Department of Medicine, Division of Clinical Pharmacology, University of Cape Town , Observatory, 7925, South Africa.
  • Barnard L; Department of Chemistry, University of Cape Town , Rondebosch 7701, South Africa.
  • Wilkinson C; Department of Chemistry, University of Cape Town , Rondebosch 7701, South Africa.
  • Njogu PM; Department of Chemistry, University of Cape Town , Rondebosch 7701, South Africa.
  • Njoroge M; Department of Pharmaceutical Chemistry, University of Nairobi , P.O. Box 19676, Nairobi, 00202, Kenya.
  • Laing L; Department of Medicine, Division of Clinical Pharmacology, University of Cape Town , Observatory, 7925, South Africa.
  • Machado M; Department of Medicine, Division of Clinical Pharmacology, University of Cape Town , Observatory, 7925, South Africa.
  • Prudêncio M; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa , Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal.
  • Reader J; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa , Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal.
  • Botha M; Department of Biochemistry, Institute for Sustainable Malaria Control, University of Pretoria , Private Bag X20, Hatfield 0028, South Africa.
  • Nondaba S; Department of Biochemistry, Institute for Sustainable Malaria Control, University of Pretoria , Private Bag X20, Hatfield 0028, South Africa.
  • Birkholtz LM; Department of Biochemistry, Institute for Sustainable Malaria Control, University of Pretoria , Private Bag X20, Hatfield 0028, South Africa.
  • Lauterbach S; Department of Biochemistry, Institute for Sustainable Malaria Control, University of Pretoria , Private Bag X20, Hatfield 0028, South Africa.
  • Churchyard A; Wits Research Institute for Malaria, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service , Johannesburg 2193, South Africa.
  • Coetzer TL; Wits Research Institute for Malaria, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service , Johannesburg 2193, South Africa.
  • Burrows JN; Wits Research Institute for Malaria, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service , Johannesburg 2193, South Africa.
  • Yeates C; Medicines for Malaria Venture , ICC, Route de Pré-Bois 20, P.O. Box 1826, 1215 Geneva, Switzerland.
  • Denti P; Inpharma Consultancy , 6 Dudley Hill Close, Welwyn, Hertfordshire AL60QQ, U.K.
  • Wiesner L; Department of Medicine, Division of Clinical Pharmacology, University of Cape Town , Observatory, 7925, South Africa.
  • Egan TJ; Department of Medicine, Division of Clinical Pharmacology, University of Cape Town , Observatory, 7925, South Africa.
  • Wittlin S; Department of Chemistry, University of Cape Town , Rondebosch 7701, South Africa.
  • Chibale K; Swiss Tropical and Public Health Institute , Socinstrasse 57, 4002 Basel, Switzerland.
J Med Chem ; 60(4): 1432-1448, 2017 02 23.
Article em En | MEDLINE | ID: mdl-28094524
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium berghei / Benzimidazóis / Malária / Antimaláricos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium berghei / Benzimidazóis / Malária / Antimaláricos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article