Angiosarcoma in HIV-negative patients is not associated with HHV-8.
An Bras Dermatol
; 91(6): 738-741, 2016.
Article
em En
| MEDLINE
| ID: mdl-28099593
ABSTRACT
BACKGROUND:
Angiosarcoma is an aggressive, malignant neoplasm of vascular or lymphatic origin. Herpes virus 8 (HHV-8) is a member of the herpes family with a tropism for endothelial cells and it has been proven to induce vascular neoplasms, such as Kaposi's sarcoma. The role of HHV-8 in the pathogenesis of angiosarcoma has not been well defined.OBJECTIVE:
To investigate the relationship between the presence of HHV-8 and angiosarcoma.METHODS:
In this study, the team investigated the relationship between the presence of HHV-8, as determined by polymerase chain reaction, and angiosarcoma, using samples from patients with epidemic Kaposi's sarcoma as controls.RESULTS:
While all control cases with epidemic Kaposi's sarcoma were positive for HHV-8, none of the angiosarcoma cases was.CONCLUSION:
These findings support most previous studies that found no association between HHV-8 and angiosarcoma.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sarcoma de Kaposi
/
Neoplasias Cutâneas
/
Infecções Oportunistas Relacionadas com a AIDS
/
Soronegatividade para HIV
/
Herpesvirus Humano 8
/
Hemangiossarcoma
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
País como assunto:
America do sul
/
Brasil
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article