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Antibody-secreting plasma cells persist for decades in human intestine.
Landsverk, Ole J B; Snir, Omri; Casado, Raquel Bartolomé; Richter, Lisa; Mold, Jeff E; Réu, Pedro; Horneland, Rune; Paulsen, Vemund; Yaqub, Sheraz; Aandahl, Einar Martin; Øyen, Ole M; Thorarensen, Hildur Sif; Salehpour, Mehran; Possnert, Göran; Frisén, Jonas; Sollid, Ludvig M; Baekkevold, Espen S; Jahnsen, Frode L.
Afiliação
  • Landsverk OJ; Department of Pathology, Centre for Immune Regulation, Oslo University Hospital-Rikshospitalet and The University of Oslo, 0372 Oslo, Norway ole.jorgen.bjarnason.landsverk@rr-research.no frode.lars.jahnsen@rr-research.no.
  • Snir O; Department of Immunology, Centre for Immune Regulation, Oslo University Hospital-Rikshospitalet and The University of Oslo, 0372 Oslo, Norway.
  • Casado RB; Department of Pathology, Centre for Immune Regulation, Oslo University Hospital-Rikshospitalet and The University of Oslo, 0372 Oslo, Norway.
  • Richter L; Department of Pathology, Centre for Immune Regulation, Oslo University Hospital-Rikshospitalet and The University of Oslo, 0372 Oslo, Norway.
  • Mold JE; Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden.
  • Réu P; Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden.
  • Horneland R; Center for Neuroscience and Cell Biology, University of Coimbra, 3000-213 Coimbra, Portugal.
  • Paulsen V; Department of Transplantation Medicine, Oslo University Hospital-Rikshospitalet, 0372 Oslo, Norway.
  • Yaqub S; Department of Transplantation Medicine, Oslo University Hospital-Rikshospitalet, 0372 Oslo, Norway.
  • Aandahl EM; Department of Gastrointestinal Surgery, Oslo University Hospital-Rikshospitalet, 0372 Oslo, Norway.
  • Øyen OM; Centre for Molecular Medicine Norway, Nordic European Molecular Biology Laboratory Partnership, Oslo University Hospital-Rikshospitalet and The University of Oslo, 0372 Oslo, Norway.
  • Thorarensen HS; Department of Transplantation Medicine, Oslo University Hospital-Rikshospitalet, 0372 Oslo, Norway.
  • Salehpour M; Department of Transplantation Medicine, Oslo University Hospital-Rikshospitalet, 0372 Oslo, Norway.
  • Possnert G; Department of Informatics, University of Oslo, 0313 Oslo, Norway.
  • Frisén J; Department of Physics and Astronomy, Ion Physics, Uppsala University, 752 36 Uppsala, Sweden.
  • Sollid LM; Department of Physics and Astronomy, Ion Physics, Uppsala University, 752 36 Uppsala, Sweden.
  • Baekkevold ES; Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden.
  • Jahnsen FL; Department of Immunology, Centre for Immune Regulation and KG Jebsen Coeliac Disease Research Centre, Oslo University Hospital-Rikshospitalet and The University of Oslo, 0372 Oslo, Norway.
J Exp Med ; 214(2): 309-317, 2017 02.
Article em En | MEDLINE | ID: mdl-28104812
ABSTRACT
Plasma cells (PCs) produce antibodies that mediate immunity after infection or vaccination. In contrast to PCs in the bone marrow, PCs in the gut have been considered short lived. In this study, we studied PC dynamics in the human small intestine by cell-turnover analysis in organ transplants and by retrospective cell birth dating measuring carbon-14 in genomic DNA. We identified three distinct PC subsets a CD19+ PC subset was dynamically exchanged, whereas of two CD19- PC subsets, CD45+ PCs exhibited little and CD45- PCs no replacement and had a median age of 11 and 22 yr, respectively. Accumulation of CD45- PCs during ageing and the presence of rotavirus-specific clones entirely within the CD19- PC subsets support selection and maintenance of protective PCs for life in human intestine.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmócitos / Intestinos Limite: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmócitos / Intestinos Limite: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article