Overexpression of AQP3 and AQP10 in the skin exacerbates psoriasiform acanthosis.
Exp Dermatol
; 26(10): 949-951, 2017 10.
Article
em En
| MEDLINE
| ID: mdl-28111811
ABSTRACT
We previously observed that aquaporin-3 and aquaporin-10 are upregulated in the epidermis of hand dermatitis patients (Med. Hypotheses, 84, 2015, 498). To address the functional relevance of this upregulation, we overexpressed AQP3/AQP10 in mice using the human K1 promoter. Combining imiquimod with detergent-containing water challenge, a common trigger in hand and other dermatitis, resulted in an increase in acanthosis in mice overexpressing AQP3 or AQP3 and AQP10. Aquaporin overexpression also drove a trend towards greater weight loss in these animals. These data support a role for cutaneous aquaporins in the pathogenesis of dermatitis and as a potential target in their treatment.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Redução de Peso
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Aquaporinas
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Dermatite
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Epiderme
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Aquaporina 3
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article