Penetration of Ciprofloxacin and Amikacin into the Alveolar Epithelial Lining Fluid of Rats with Pulmonary Fibrosis.

Ni, Wentao; Yang, Deqing; Mei, Hekun; Zhao, Jin; Liang, Beibei; Bai, Nan; Chai, Dong; Cui, Junchang; Wang, Rui; Liu, Youning

Ni, Wentao; Yang, Deqing; Mei, Hekun; Zhao, Jin; Liang, Beibei; Bai, Nan; Chai, Dong; Cui, Junchang; Wang, Rui; Liu, Youning.

Afiliação

Ni W; Department of Respiratory Diseases, Chinese PLA General Hospital, Beijing, China.
Yang D; School of Pharmacy and Chemistry, Dali University, Yunnan, China.
Mei H; Department of Clinical Pharmacology, Chinese PLA General Hospital, Beijing, China.
Zhao J; Department of Respiratory Diseases, Chinese PLA General Hospital, Beijing, China.
Liang B; Department of Clinical Pharmacology, Chinese PLA General Hospital, Beijing, China.
Bai N; Department of Clinical Pharmacology, Chinese PLA General Hospital, Beijing, China.
Chai D; Department of Clinical Pharmacology, Chinese PLA General Hospital, Beijing, China chai301pharmacy@163.com liuyouningpla301@163.com.
Cui J; Department of Respiratory Diseases, Chinese PLA General Hospital, Beijing, China.
Wang R; Department of Clinical Pharmacology, Chinese PLA General Hospital, Beijing, China.
Liu Y; Department of Respiratory Diseases, Chinese PLA General Hospital, Beijing, China chai301pharmacy@163.com liuyouningpla301@163.com.

Antimicrob Agents Chemother ; 61(4)2017 04.

Article em En | MEDLINE | ID: mdl-28115351

Assuntos

Amicacina/farmacocinética; Antibacterianos/farmacocinética; Líquido da Lavagem Broncoalveolar/química; Ciprofloxacina/farmacocinética; Fibrose Pulmonar/metabolismo; Mucosa Respiratória/metabolismo; Amicacina/sangue; Animais; Antibacterianos/sangue; Área Sob a Curva; Disponibilidade Biológica; Transporte Biológico; Bleomicina; Ciprofloxacina/sangue; Injeções Intravenosas; Pulmão/metabolismo; Pulmão/patologia; Masculino; Permeabilidade; Fibrose Pulmonar/induzido quimicamente; Fibrose Pulmonar/patologia; Ratos; Ratos Sprague-Dawley; Mucosa Respiratória/patologia

Palavras-chave

amikacin; ciprofloxacin; epithelial lining fluid; penetration; pulmonary fibrosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrose Pulmonar / Líquido da Lavagem Broncoalveolar / Amicacina / Ciprofloxacina / Mucosa Respiratória / Antibacterianos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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