Microbial production of astilbin, a bioactive rhamnosylated flavanonol, from taxifolin.

Thuan, Nguyen Huy; Malla, Sailesh; Trung, Nguyen Thanh; Dhakal, Dipesh; Pokhrel, Anaya Raj; Chu, Luan Luong; Sohng, Jae Kyung

Thuan, Nguyen Huy; Malla, Sailesh; Trung, Nguyen Thanh; Dhakal, Dipesh; Pokhrel, Anaya Raj; Chu, Luan Luong; Sohng, Jae Kyung.

Afiliação

Thuan NH; Center for Molecular Biology, Institute of Research and Development, Duy Tan University, K7/25 Quang Trung, Danang, Vietnam. thuanbiochem@gmail.com.
Malla S; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet, 2800, Kongens Lyngby, Denmark.
Trung NT; Center for Molecular Biology, Institute of Research and Development, Duy Tan University, K7/25 Quang Trung, Danang, Vietnam.
Dhakal D; Department of Life Science and Biochemical Engineering, SunMoon University, 70 Sunmoon-ro 221, Tangjeong-myeon, Asan-si, Chungnam, 31460, Republic of Korea.
Pokhrel AR; Department of Life Science and Biochemical Engineering, SunMoon University, 70 Sunmoon-ro 221, Tangjeong-myeon, Asan-si, Chungnam, 31460, Republic of Korea.
Chu LL; Department of Life Science and Biochemical Engineering, SunMoon University, 70 Sunmoon-ro 221, Tangjeong-myeon, Asan-si, Chungnam, 31460, Republic of Korea.
Sohng JK; Department of Life Science and Biochemical Engineering, SunMoon University, 70 Sunmoon-ro 221, Tangjeong-myeon, Asan-si, Chungnam, 31460, Republic of Korea. sohng@sunmoon.ac.kr.

World J Microbiol Biotechnol ; 33(2): 36, 2017 Feb.

Article em En | MEDLINE | ID: mdl-28120309

Assuntos

Antineoplásicos/farmacologia; Flavonóis/biossíntese; Glicosiltransferases/metabolismo; Quercetina/análogos & derivados; Ramnose/metabolismo; Antineoplásicos/química; Proteínas de Arabidopsis/genética; Proteínas de Arabidopsis/metabolismo; Vias Biossintéticas; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Escherichia coli/enzimologia; Escherichia coli/genética; Técnicas de Inativação de Genes; Engenharia Genética/métodos; Glicosilação; Glicosiltransferases/genética; Humanos; Quercetina/metabolismo; Quercetina/farmacologia

Palavras-chave

Biotransformation; Cytotoxicity; Escherichia coli; Flavonoid; Glycosylation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quercetina / Ramnose / Glicosiltransferases / Flavonóis / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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